Detection of three distinct patterns of T helper cell dysfunction in asymptomatic, human immunodeficiency virus-seropositive patients. Independence of CD4+ cell numbers and clinical staging.

Clerici, Mario; I Stocks, N; A Zajac, R; N. Boswell, R.; R. Lucey, Daniel; S. Via, Charles; M Shearer, G

doi:10.1172/jci114376

Public

Detection of three distinct patterns of T helper cell dysfunction in asymptomatic, human immunodeficiency virus-seropositive patients. Independence of CD4+ cell numbers and clinical staging.

Published in Journal of Clinical Investigation • Dec 1, 1989

Authors:

Mario Clerici

N I Stocks

R A Zajac

Abstract

We have tested the T helper cell (TH) potential of asymptomatic, HIV seropositive (HIV+) patients, using an in vitro assay for IL-2 production. Peripheral blood leukocytes (PBL) from 74 HIV+ patients and 70 HIV- control donors were tested for TH function when stimulated with influenza A virus (FLU),...

Subject

Asymptomatic

Immunology

CD8

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