IL-17 Promotes Bone Erosion in Murine Collagen-Induced Arthritis Through Loss of the Receptor Activator of NF-κB Ligand/Osteoprotegerin Balance

Lubberts, Erik; van den Bersselaar, Liduine; Oppers‐Walgreen, Birgitte; Schwarzenberger, Paul; J. J. Coenen‐de Roo, Christina; K. Kolls, Jay; A. B. Joosten, Leo; B. van den Berg, Wim

doi:10.4049/jimmunol.170.5.2655

Public

IL-17 Promotes Bone Erosion in Murine Collagen-Induced Arthritis Through Loss of the Receptor Activator of NF-κB Ligand/Osteoprotegerin Balance

Published in The Journal of Immunology • Mar 1, 2003

Authors:

Erik Lubberts

Liduine van den Bersselaar

Birgitte Oppers‐Walgreen

Abstract

IL-17 is a T cell-derived proinflammatory cytokine in experimental arthritis and is a stimulator of osteoclastogenesis in vitro. In this study, we report the effects of IL-17 overexpression (AdIL-17) in the knee joint of type II collagen-immunized mice on bone erosion and synovial receptor activator...

Subject

RANKL

Osteoprotegerin

Proinflammatory cytokine

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