Myeloid-Derived Suppressor Cells Suppress Antitumor Immune Responses through IDO Expression and Correlate with Lymph Node Metastasis in Patients with Breast Cancer

Yu, Jinpu; Du, Weijiao; Fang, Yan; Wang, Yue; Li, Hui; Cao, Shui; Yu, Wenwen; Shen, Chun; Liu, Juntian; Ren, Xiubao

doi:10.4049/jimmunol.1201449

Public

Myeloid-Derived Suppressor Cells Suppress Antitumor Immune Responses through IDO Expression and Correlate with Lymph Node Metastasis in Patients with Breast Cancer

Published in The Journal of Immunology • Feb 26, 2013

Authors:

Jinpu Yu

Weijiao Du

Yan Fang

Abstract

Myeloid-derived suppressor cells (MDSCs) represent heterogeneous immunosuppressive cells in multiple cancer types and display potent immunosuppressive activity on T cells. We have shown the increased expression of IDO in breast cancer. Because IDO plays a pivotal role in immune tolerance via suppres...

Subject

Immune system

Medicine

Suppressor

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!