Maintenance of the Gag/Gag-Pol Ratio Is Important for Human Immunodeficiency Virus Type 1 RNA Dimerization and Viral Infectivity

Shehu-Xhilaga, Miranda; M. Crowe, Suzanne; Mak, Johnson

doi:10.1128/jvi.75.4.1834-1841.2001

Public

Maintenance of the Gag/Gag-Pol Ratio Is Important for Human Immunodeficiency Virus Type 1 RNA Dimerization and Viral Infectivity

Published in Journal of Virology • Feb 15, 2001

Authors:

Miranda Shehu-Xhilaga

Suzanne M. Crowe

Johnson Mak

Abstract

Production of the human immunodeficiency virus type 1 (HIV-1) Gag-Pol precursor protein results from a -1 ribosomal frameshifting event. In infected cells, this generates Gag and Gag-Pol in a ratio that is estimated to be 20:1, a ratio that is conserved among retroviruses. To examine the impact of t...

Subject

Biology

Group-specific antigen

Reverse transcriptase

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