Host Recognition of Bacterial Muramyl Dipeptide Mediated through NOD2

Inohara, Naohiro; Ogura, Yasunori; Fontalba, Ana; Gutiérrez, Olga; Pons, Fernando; Crespo, Javier; Fukase, Koichi; Inamura, Seiichi; Kusumoto, Shoichi; Hashimoto, Masahito; J. Foster, Simon; P. Moran, Anthony; L. Fernández-Luna, José; Núñez, Gabriel

doi:10.1074/jbc.c200673200

Public

Host Recognition of Bacterial Muramyl Dipeptide Mediated through NOD2

Published in Journal of Biological Chemistry • Feb 1, 2003

Authors:

Naohiro Inohara

Yasunori Ogura

Ana Fontalba

Abstract

NOD2, a protein associated with susceptibility to Crohn's disease, confers responsiveness to bacterial preparations of lipopolysaccharide and peptidoglycan, but the precise moiety recognized remains elusive. Biochemical and functional analyses identified muramyl dipeptide (MurNAc-L-Ala-D-isoGln) der...

Subject

Muramyl dipeptide

NOD2

Dipeptide

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