Pharmacology and pathophysiology of mutated KCNJ5 found in adrenal aldosterone-producing adenomas.

Tauber, P; Penton, D; Stindl, J; Humberg, E; Tegtmeier, I; Sterner, C; Beuschlein, F; Reincke, M; Barhanin, J; Bandulik, S; Warth, R

doi:10.1210/en.2013-1944

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Pharmacology and pathophysiology of mutated KCNJ5 found in adrenal aldosterone-producing adenomas.

Shared by NobleBlocks on Apr 1, 2014 • 12:00 AM UTC

Authors:

P Tauber

D Penton

J Stindl

Abstract

Somatic mutations of the potassium channel KCNJ5 are found in 40% of aldosterone producing adenomas (APAs). APA-related mutations of KCNJ5 lead to a pathological Na(+) permeability and a rise in cytosolic Ca(2+), the latter presumably by depolarizing the membrane and activating voltage-gated Ca(2+) ...

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