Superoxide Modulates the Oxidation and Nitrosation of Thiols by Nitric Oxide-derived Reactive Intermediates

A. Wink, David; A. Cook, John; Y. Kim, Sungmee; Vodovotz, Yoram; Pacelli, Roberto; C. Krishna, Murali; Russo, Angelo; B. Mitchell, James; Jourd’heuil, David; M. Miles, Allen; B. Grisham, Matthew

doi:10.1074/jbc.272.17.11147

Public

Superoxide Modulates the Oxidation and Nitrosation of Thiols by Nitric Oxide-derived Reactive Intermediates

Published in Journal of Biological Chemistry • Apr 1, 1997

Authors:

David A. Wink

John A. Cook

Sungmee Y. Kim

Abstract

Thiol-containing proteins are key to numerous cellular processes, and their functions can be modified by thiol nitrosation or oxidation. Nitrosation reactions are quenched by O2·¯, while the oxidation chemistry mediated by peroxynitrite is quenched by excess flux of either NO or O2·¯. A solution of ...

Subject

Peroxynitrite

Chemistry

Nitrosation

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