Haplotype analysis of ABCB1/MDR1 blocks in a Japanese population reveals genotype-dependent renal clearance of irinotecan.

K, Sai; N, Kaniwa; M, Itoda; Y, Saito; R, Hasegawa; K, Komamura; K, Ueno; S, Kamakura; M, Kitakaze; K, Shirao; H, Minami; A, Ohtsu; T, Yoshida; N, Saijo; Y, Kitamura; N, Kamatani; S, Ozawa; J, Sawada

doi:10.1097/00008571-200312000-00005

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Haplotype analysis of ABCB1/MDR1 blocks in a Japanese population reveals genotype-dependent renal clearance of irinotecan.

Shared by NobleBlocks on Dec 1, 2003 • 12:00 AM UTC

Authors:

Sai K

Kaniwa N

Itoda M

Abstract

We performed comprehensive haplotyping of ABCB1/MDR1 gene blocks using 49 genetic polymorphisms, including seven novel ones, obtained from 145 Japanese subjects. The ABCB1/MDR1 gene was divided into four blocks (Blocks -1, 1, 2, and 3) based on linkage disequilibrium analysis of polymorphisms. Using...

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