Effects of AIN457, a Fully Human Antibody to Interleukin-17A, on Psoriasis, Rheumatoid Arthritis, and Uveitis

Hueber, Wolfgang; D. Patel, Dhavalkumar; P. Dryja, Thaddeus; Wright, A.; А. Королева, И.; Bruin, Gerard; Antoni, Christian; Draelos, Zoe; H. Gold, Michael; Psoriasis Study Group, the; Durez, Patrick; P. Tak, Paul; J. Gómez‐Reino, Juan; Rheumatoid Arthritis Study Group, the; Stephen Foster, C.; Y. Kim, Rosa; Michael Samson, C.; S. Falk, Naomi; Chu, David; Callanan, David; Dong Nguyen, Quan; Uveitis Study Group, the; Rose, Kristine; Haider, Asifa; Di Padova, Franco

doi:10.1126/scitranslmed.3001107

Public

Effects of AIN457, a Fully Human Antibody to Interleukin-17A, on Psoriasis, Rheumatoid Arthritis, and Uveitis

Published in Science Translational Medicine • Oct 6, 2010

Authors:

Wolfgang Hueber

Dhavalkumar D. Patel

Thaddeus P. Dryja

Abstract

Interleukin-17A (IL-17A) is elaborated by the T helper 17 (T(H)17) subset of T(H) cells and exhibits potent proinflammatory properties in animal models of autoimmunity, including collagen-induced arthritis, experimental autoimmune encephalomyelitis, and experimental autoimmune uveitis. To determine ...

Subject

Psoriasis

Rheumatoid arthritis

Medicine

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