Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets

Imai, Masaki; Watanabe, Tokiko; Hatta, Masato; C. Das, Subash; Ozawa, Makoto; Shinya, Kyoko; Zhong, Gongxun; Hanson, Anthony; Katsura, Hiroaki; Watanabe, Shinji; Li, Chengjun; Kawakami, Eiryo; Yamada, Shinya; Kiso, Maki; Suzuki, Yasuo; A. Maher, Eileen; Neumann, Gabriele; Kawaoka, Yoshihiro

doi:10.1038/nature10831

Public

Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets

Published in Nature • May 1, 2012

Authors:

Masaki Imai

Tokiko Watanabe

Masato Hatta

Abstract

Only four mutations in H5N1 HA are required to enable ferret-to-ferret transmission of a reassortant virus containing the H5 HA and the remaining seven gene segments from a human pandemic H1N1 influenza virus. Whether avian H5N1 viruses can gain the ability to transmit between humans was uncertain. ...

Subject

Influenza A virus subtype H5N1

Virology

Biology

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