HLA-B*5701 Screening for Hypersensitivity to Abacavir

Mallal, S.; J. Phillips, Elizabeth; Carosi, Giampiero; Molina, Jean‐Michel; Workman, Cassy; Tomažič, Janez; Jägel-Guedes, E.; Rugină, Sorin; А. Козырев, О.; Flores Cid, Juan; Hay, Phillip; Nolan, David; Hughes, Sara; R. Hughes, Arlene; Ryan, Susanna; J Fitch, N; Thorborn, D.; Benbow, Alastair

doi:10.1056/nejmoa0706135

Public

HLA-B*5701 Screening for Hypersensitivity to Abacavir

Published in New England Journal of Medicine • Feb 6, 2008

Authors:

S. Mallal

Elizabeth J. Phillips

Giampiero Carosi

Abstract

BACKGROUND: Hypersensitivity reaction to abacavir is strongly associated with the presence of the HLA-B*5701 allele. This study was designed to establish the effectiveness of prospective HLA-B*5701 screening to prevent the hypersensitivity reaction to abacavir. METHODS: This double-blind, prospectiv...

Subject

Abacavir

Medicine

Prospective cohort study

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