Colon-specific delivery of a probiotic-derived soluble protein ameliorates intestinal inflammation in mice through an EGFR-dependent mechanism

Yan, Fang; Cao, Hanwei; L. Cover, Timothy; Kay Washington, M.; Shi, Yan; Liu, LinShu; Chaturvedi, Rupesh; M. Peek, Richard; T. Wilson, Keith; Brent Polk, D.

doi:10.1172/jci44031

Public

Colon-specific delivery of a probiotic-derived soluble protein ameliorates intestinal inflammation in mice through an EGFR-dependent mechanism

Published in Journal of Clinical Investigation • May 23, 2011

Authors:

Fang Yan

Hanwei Cao

Timothy L. Cover

Abstract

Probiotic bacteria can potentially have beneficial effects on the clinical course of several intestinal disorders, but our understanding of probiotic action is limited. We have identified a probiotic bacteria-derived soluble protein, p40, from Lactobacillus rhamnosus GG (LGG), which prevents cytokin...

Subject

Mechanism (biology)

Probiotic

Inflammation

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