Initial Use of Ambrisentan plus Tadalafil in Pulmonary Arterial Hypertension

Galiè, Nazzareno; Albert Barberà, Joan; Frost, Adaani; Ghofrani, Hossein-Ardeschir; M. Hoeper, Marius; V. McLaughlin, Vallerie; J. Peacock, Andrew; Simonneau, Gérald; Vachiéry, Jean‐Luc; Grünig, Ekkehard; J. Oudiz, Ronald; Vonk Noordegraaf, Anton; James White, R.; Blair, Christiana; Gillies, Hunter; Miller, Karen; Harris, Julia; Langley, Jonathan; J. Rubin, Lewis

doi:10.1056/nejmoa1413687

Public

Initial Use of Ambrisentan plus Tadalafil in Pulmonary Arterial Hypertension

Published in New England Journal of Medicine • Aug 26, 2015

Authors:

Nazzareno Galiè

Joan Albert Barberà

Adaani Frost

Abstract

BACKGROUND: Data on the effect of initial combination therapy with ambrisentan and tadalafil on long-term outcomes in patients with pulmonary arterial hypertension are scarce. METHODS: In this event-driven, double-blind study, we randomly assigned, in a 2:1:1 ratio, participants with World Health Or...

Subject

Ambrisentan

Tadalafil

Medicine

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