Phase I Pharmacokinetic and Pharmacodynamic Study of 17-Allylamino, 17-Demethoxygeldanamycin in Patients With Advanced Malignancies

Banerji, Udai; O’Donnell, Anne; Scurr, Michelle; Pacey, Simon; Stapleton, Sarah; J. Asad, Yasmin; K. Simmons, Laura; Maloney, Alison; I. Raynaud, Florence; Campbell, Maeli; I. Walton, Michael; R. Lakhani, Sunil; B. Kaye, Stanley; Workman, Paul; Judson, Ian

doi:10.1200/jco.2005.00.612

Public

Phase I Pharmacokinetic and Pharmacodynamic Study of 17-Allylamino, 17-Demethoxygeldanamycin in Patients With Advanced Malignancies

Published in Journal of Clinical Oncology • Jun 17, 2005

Authors:

Udai Banerji

Anne O’Donnell

Michelle Scurr

Abstract

PURPOSE: To study the toxicity and pharmacokinetic-pharmacodynamic profile of 17-allylamino, 17- demethoxygeldanamycin (17-AAG) and to recommend a dose for phase II trials. PATIENTS AND METHODS: This was a phase I study examining a once-weekly dosing schedule of 17-AAG. Thirty patients with advanced...

Subject

Medicine

Pharmacokinetics

Pharmacodynamics

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