Reactive oxygen species alter brain endothelial tight junction dynamics via RhoA, PI3 kinase, and PKB signaling

Schreibelt, Gerty; Kooij, Gijs; Reijerkerk, Arie; van Doorn, Ruben; I. Gringhuis, Sonja; M. A. van der Pol, Susanne; B. Weksler, Babette; A. Romero, Ignacio; Couraud, Pierre‐Olivier; Piontek, Jörg; E. Blasig, Ingolf; D. Dijkstra, Christine; Ronken, Eric; E. de Vries, Helga

doi:10.1096/fj.07-8329com

Public

Reactive oxygen species alter brain endothelial tight junction dynamics via RhoA, PI3 kinase, and PKB signaling

Published in The FASEB Journal • Jun 22, 2007

Authors:

Gerty Schreibelt

Gijs Kooij

Arie Reijerkerk

Abstract

ABSTRACT The blood‐brain barrier (BBB) prevents the entrance of circulating molecules and immune cells into the central nervous system. The barrier is formed by specialized brain endothelial cells that are interconnected by tight junctions (TJ). A defective function of the BBB has been described for...

Subject

RHOA

Cell biology

Occludin

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!