A Novel Mechanism of Rapid Nuclear Neutrophil Extracellular Trap Formation in Response to <i>Staphylococcus aureus</i>

H. Pilsczek, Florian; Salina, Davide; Poon, Karen; Fahey, Candace; G. Yipp, Bryan; D. Sibley, Christopher; M. Robbins, Stephen; H. Y. Green, Francis; G. Surette, Mike; Sugai, Motoyuki; Gabriela Bowden, M.; Hussain, Muzaffar; Zhang, Kunyan; Kubes, Paul

doi:10.4049/jimmunol.1000675

Public

A Novel Mechanism of Rapid Nuclear Neutrophil Extracellular Trap Formation in Response to Staphylococcus aureus

Published in The Journal of Immunology • Nov 23, 2010

Authors:

Florian H. Pilsczek

Davide Salina

Karen Poon

Abstract

Neutrophil extracellular traps (NETs) are webs of DNA covered with antimicrobial molecules that constitute a newly described killing mechanism in innate immune defense. Previous publications reported that NETs take up to 3-4 h to form via an oxidant-dependent event that requires lytic death of neutr...

Subject

Neutrophil extracellular traps

Cell biology

Staphylococcus aureus

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!