Tolvaptan in Patients with Autosomal Dominant Polycystic Kidney Disease

E. Torres, Vicente; B. Chapman, Arlene; Devuyst, Olivier; T. Gansevoort, Ron; J. Grantham, Jared; Higashihara, Eiji; D. Perrone, Ronald; B. Krasa, Holly; Ouyang, John; S. Czerwiec, Frank

doi:10.1056/nejmoa1205511

Public

Tolvaptan in Patients with Autosomal Dominant Polycystic Kidney Disease

Published in New England Journal of Medicine • Nov 3, 2012

Authors:

Vicente E. Torres

Arlene B. Chapman

Olivier Devuyst

Abstract

BACKGROUND: The course of autosomal dominant polycystic kidney disease (ADPKD) is often associated with pain, hypertension, and kidney failure. Preclinical studies indicated that vasopressin V(2)-receptor antagonists inhibit cyst growth and slow the decline of kidney function. METHODS: In this phase...

Subject

Tolvaptan

Autosomal dominant polycystic kidney disease

Medicine

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