A Double-Negative Feedback Loop between ZEB1-SIP1 and the microRNA-200 Family Regulates Epithelial-Mesenchymal Transition

P. Bracken, Cameron; A. Gregory, Philip; Kolesnikoff, Natasha; G. Bert, Andrew; Wang, Jun; Shannon, M; J. Goodall, Gregory

doi:10.1158/0008-5472.can-08-1942

Public

A Double-Negative Feedback Loop between ZEB1-SIP1 and the microRNA-200 Family Regulates Epithelial-Mesenchymal Transition

Published in Cancer Research • Sep 30, 2008

Authors:

Cameron P. Bracken

Philip A. Gregory

Natasha Kolesnikoff

Abstract

Epithelial to mesenchymal transition occurs during embryologic development to allow tissue remodeling and is proposed to be a key step in the metastasis of epithelial-derived tumors. The miR-200 family of microRNAs plays a major role in specifying the epithelial phenotype by preventing expression of...

Subject

microRNA

Epithelial–mesenchymal transition

Repressor

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