Inducible nitric oxide synthase‐deficient mice have enhanced leukocyte–endothelium interactions in endotoxemia

J. Hickey, Michael; A. Sharkey, Keith; Sihota, Elaine; Reinhardt, Paul; D. Macmickeng, John; Nathan, Carl; Kubes, Paul

doi:10.1096/fasebj.11.12.9337148

Public

Inducible nitric oxide synthase‐deficient mice have enhanced leukocyte–endothelium interactions in endotoxemia

Published in The FASEB Journal • Oct 1, 1997

Authors:

Michael J. Hickey

Keith A. Sharkey

Elaine Sihota

Abstract

Nitric oxide (NO) from constitutive NO synthase (NOS) has been postulated to be a homeostatic regulator of leukocyte-endothelial cell interactions. By contrast, the inducible NO synthase (iNOS) isoform has been invoked as a potential pathogenic enzyme in numerous inflammatory diseases. The objective...

Subject

Intravital microscopy

Nitric oxide synthase

Cremaster muscle

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