Inducible nitric oxide synthase-deficient mice have enhanced leukocyte-endothelium interactions in endotoxemia.

MJ, Hickey; KA, Sharkey; EG, Sihota; PH, Reinhardt; JD, Macmicking; C, Nathan; P, Kubes

doi:10.1096/fasebj.11.12.9337148

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Inducible nitric oxide synthase-deficient mice have enhanced leukocyte-endothelium interactions in endotoxemia.

Shared by NobleBlocks on Oct 1, 1997 • 12:00 AM UTC

Authors:

Hickey MJ

Sharkey KA

Sihota EG

Abstract

Nitric oxide (NO) from constitutive NO synthase (NOS) has been postulated to be a homeostatic regulator of leukocyte-endothelial cell interactions. By contrast, the inducible NO synthase (iNOS) isoform has been invoked as a potential pathogenic enzyme in numerous inflammatory diseases. The objective...

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