Negative Feedback Loop of Wnt Signaling through Upregulation of Conductin/Axin2 in Colorectal and Liver Tumors

Lustig, Barbara; Jerchow, Boris; M. Sachs, Martin; Weiler, Sigrid; Pietsch, Torsten; Karsten, Uwe; van de Wetering, Marc; Clevers, Hans; M. Schlag, Peter; Birchmeier, Walter; Behrens, Jürgen

doi:10.1128/mcb.22.4.1184-1193.2002

Public

Negative Feedback Loop of Wnt Signaling through Upregulation of Conductin/Axin2 in Colorectal and Liver Tumors

Published in Molecular and Cellular Biology • Feb 1, 2002

Authors:

Barbara Lustig

Boris Jerchow

Martin M. Sachs

Abstract

Activation of Wnt signaling through beta-catenin/TCF complexes is a key event in the development of various tumors, in particular colorectal and liver tumors. Wnt signaling is controlled by the negative regulator conductin/axin2/axil, which induces degradation of beta-catenin by functional interacti...

Subject

Wnt signaling pathway

AXIN2

Downregulation and upregulation

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