Multifunctionality of the β‐thymosin/WH2 module: G‐actin sequestration, actin filament growth, nucleation, and severing

Husson, Clotilde; Cantrelle, François‐Xavier; Roblin, Pierre; Didry, Dominique; Ho Diep Le, Kim; Perez, Javier; Guittet, Eric; Van Heijenoort, Carine; Renault, Louis; Carlier, Marie‐France

doi:10.1111/j.1749-6632.2010.05473.x

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Multifunctionality of the β‐thymosin/WH2 module: G‐actin sequestration, actin filament growth, nucleation, and severing

Shared by NobleBlocks on May 1, 2010 • 12:00 AM UTC

Authors:

Clotilde Husson

François‐Xavier Cantrelle

Pierre Roblin

Abstract

The β‐thymosin/WH2 actin‐binding module shows an amazing adaptation to multifunctionality. The β‐thymosins are genuine G‐actin sequesterers of moderate affinity for G‐actin, allowing an efficient regulation of the G‐actin/F‐actin ratio in cells by amplifying changes in the critical concentration for...

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