Multifunctionality of the β‐thymosin/WH2 module: G‐actin sequestration, actin filament growth, nucleation, and severing

Husson, Clotilde; Cantrelle, François‐Xavier; Roblin, Pierre; Didry, Dominique; Le, Kim; Pérez, Javier; Guittet, Éric; van Heijenoort, Carine; Renault, Louis; Carlier, Marie‐France

doi:10.1111/j.1749-6632.2010.05473.x

Public

Multifunctionality of the β‐thymosin/WH2 module: G‐actin sequestration, actin filament growth, nucleation, and severing

Published in Annals of the New York Academy of Sciences • May 1, 2010

Authors:

Clotilde Husson

François‐Xavier Cantrelle

Pierre Roblin

Abstract

The beta-thymosin/WH2 actin-binding module shows an amazing adaptation to multifunctionality. The beta-thymosins are genuine G-actin sequesterers of moderate affinity for G-actin, allowing an efficient regulation of the G-actin/F-actin ratio in cells by amplifying changes in the critical concentrati...

Subject

MDia1

Actin-binding protein

Actin

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