Abatacept in B7-1-positive proteinuric kidney disease.

CC, Yu; A, Fornoni; A, Weins; S, Hakroush; D, Maiguel; J, Sageshima; L, Chen; G, Ciancio; MH, Faridi; D, Behr; KN, Campbell; JM, Chang; HC, Chen; J, Oh; C, Faul; MA, Arnaout; P, Fiorina; V, Gupta; A, Greka; GW 3rd, Burke; P, Mundel

doi:10.1056/nejmoa1304572

Public

Abatacept in B7-1-positive proteinuric kidney disease.

Shared by NobleBlocks on Nov 8, 2013 • 12:00 AM UTC

Authors:

Yu CC

Fornoni A

Weins A

Abstract

Abatacept (cytotoxic T-lymphocyte-associated antigen 4-immunoglobulin fusion protein [CTLA-4-Ig]) is a costimulatory inhibitor that targets B7-1 (CD80). The present report describes five patients who had focal segmental glomerulosclerosis (FSGS) (four with recurrent FSGS after transplantation and on...

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