Nutlin-3a Activates p53 to Both Down-regulate Inhibitor of Growth 2 and Up-regulate <i>mir-34a, mir-34b,</i> and <i>mir-34c</i> Expression, and Induce Senescence

Kumamoto, Kensuke; A. Spillare, Elisa; Fujita, Kaori; Horikawa, Izumi; Yamashita, Taro; Appella, Ettore; Nagashima, Makoto; Takenoshita, Seiichi; Yokota, Jun; C. Harris, Curtis

doi:10.1158/0008-5472.can-07-2780

Public

Nutlin-3a Activates p53 to Both Down-regulate Inhibitor of Growth 2 and Up-regulate mir-34a, mir-34b, and mir-34c Expression, and Induce Senescence

Published in Cancer Research • May 1, 2008

Authors:

Kensuke Kumamoto

Elisa A. Spillare

Kaori Fujita

Abstract

Nutlin-3, an MDM2 inhibitor, activates p53, resulting in several types of cancer cells undergoing apoptosis. Although p53 is mutated or deleted in approximately 50% of all cancers, p53 is still functionally active in the other 50%. Consequently, nutlin-3 and similar drugs could be candidates for neo...

Subject

Gene knockdown

Senescence

Chromatin immunoprecipitation

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