Protective T cell immunity in mice following protein-TLR7/8 agonist-conjugate immunization requires aggregation, type I IFN, and multiple DC subsets

Kastenmüller, Kathrin; Wille-Reece, Ulrike; Lindsay, Ross; Trager, Lauren; A. Darrah, Patricia; J. Flynn, Barbara; Becker, Maria; C. Udey, Mark; E. Clausen, Björn; Z. Igyártó, Botond; H. Kaplan, Daniel; Kastenmüller, Wolfgang; N. Germain, Ronald; A. Seder, Robert

doi:10.1172/jci45416

Public

Protective T cell immunity in mice following protein-TLR7/8 agonist-conjugate immunization requires aggregation, type I IFN, and multiple DC subsets

Published in Journal of Clinical Investigation • Apr 25, 2011

Authors:

Kathrin Kastenmüller

Ulrike Wille-Reece

Ross Lindsay

Abstract

The success of a non-live vaccine requires improved formulation and adjuvant selection to generate robust T cell immunity following immunization. Here, using protein linked to a TLR7/8 agonist (conjugate vaccine), we investigated the functional properties of vaccine formulation, the cytokines, and t...

Subject

T cell

CD8

Immunology

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