Clinically used antirheumatic agent auranofin is a proteasomal deubiquitinase inhibitor and inhibits tumor growth.

Liu, Ningning; Li, Xiaofen; Huang, Hongbiao; Zhao, Chong; Liao, Siyan; Yang, Changshan; Liu, Shouting; Song, Wenbin; Lu, Xiaoyu; Lan, Xiaoying; Chen, Xin; Yi, Songgang; Xu, Li; Jiang, Lili; Zhao, Canguo; Dong, Xiaoxian; Zhou, Ping; Li, Shujue; Wang, Shunqing; Shi, Xianping; Q Dou, Ping; Wang, Xuejun; Liu, Jinbao

doi:10.18632/oncotarget.2113

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Clinically used antirheumatic agent auranofin is a proteasomal deubiquitinase inhibitor and inhibits tumor growth.

Shared by NobleBlocks on Jul 30, 2014 • 12:00 AM UTC

Authors:

Ningning Liu

Xiaofen Li

Hongbiao Huang

Abstract

Proteasomes are attractive emerging targets for anti-cancer therapies. Auranofin (Aur), a gold-containing compound clinically used to treat rheumatic arthritis, was recently approved by US Food and Drug Administration for Phase II clinical trial to treat cancer but its anti-cancer mechanism is poorl...

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