The impact of CYP2C9 and VKORC1 genetic polymorphism and patient characteristics upon warfarin dose requirements: proposal for a new dosing regimen

Sconce, Elizabeth; Khan, Tayyaba; Wynne, Hilary; Avery, Peter; Monkhouse, Louise; P. King, Barry; Wood, Peter; Kesteven, Patrick; K. Daly, Ann; Kamali, Farhad

doi:10.1182/blood-2005-03-1108

Public

The impact of CYP2C9 and VKORC1 genetic polymorphism and patient characteristics upon warfarin dose requirements: proposal for a new dosing regimen

Published in Blood • Jun 10, 2005

Authors:

Elizabeth Sconce

Tayyaba Khan

Hilary Wynne

Abstract

Current dosing algorithms do not account for genetic and environmental factors for warfarin dose determinations. This study investigated the contribution of age, CYP2C9 and VKORC1 genotype, and body size to warfarin-dose requirements. Studied were 297 patients with stable anticoagulation with a targ...

Subject

VKORC1

Warfarin

CYP2C9

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