Mechanisms of Acquired Crizotinib Resistance in ALK-Rearranged Lung Cancers

Katayama, Ryohei; T. Shaw, Alice; M. Khan, Tahsin; Mino-Kenudson, Mari; J. Solomon, Benjamin; Halmos, Balazs; A. Jessop, Nicholas; C. Wain, John; Tien Yeo, Alan; Benes, Cyril; Drew, Lisa; Carlos Saeh, Jamal; Crosby, Katherine; V. Sequist, Lecia; John Iafrate, A.; A. Engelman, Jeffrey

doi:10.1126/scitranslmed.3003316

Public

Mechanisms of Acquired Crizotinib Resistance in ALK-Rearranged Lung Cancers

Shared by NobleBlocks on Feb 8, 2012 • 12:00 AM UTC

Authors:

Ryohei Katayama

Alice T. Shaw

Tahsin M. Khan

Abstract

Multiple mechanisms of crizotinib resistance were identified in lung cancer patients including new secondary ALK mutations and activation of receptor tyrosine kinases.

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