Cellular differentiation hierarchies in normal and culture-adapted human embryonic stem cells

Enver, Tariq; Soneji, Shamit; Joshi, Chirag; Brown, John; J. Iborra, Francisco; Ørntoft, Torben; Thykjær, Thomas; L. Maltby, Edna; Smith, Kath; Abu Dawud, Raed; Jones, Mark; Moghaddam Matin, Maryam; J. Gokhale, Paul; S. Draper, Jonathan; W. Andrews, Peter

doi:10.1093/hmg/ddi345

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Cellular differentiation hierarchies in normal and culture-adapted human embryonic stem cells

Published in Human Molecular Genetics • Sep 13, 2005

Authors:

Tariq Enver

Shamit Soneji

Chirag Joshi

Abstract

Human embryonic stem cell (HESC) lines vary in their characteristics and behaviour not only because they are derived from genetically outbred populations, but also because they may undergo progressive adaptation upon long-term culture in vitro. Such adaptation may reflect selection of variants with ...

Subject

Biology

Embryonic stem cell

Stem cell

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