<i>In vitro</i> biological activity of a novel small-molecule inhibitor of polo-like kinase 1

J. Lansing, Timothy; T. McConnell, Randy; R. Duckett, Derek; Spehar, Glenn; B. Knick, Victoria; F. Hassler, Daniel; Noro, Nobuhiro; Furuta, Masaaki; A. Emmitte, Kyle; M. Gilmer, Tona; A. Mook, Robert; Cheung, Mui

doi:10.1158/1535-7163.mct-06-0543

Public

In vitro biological activity of a novel small-molecule inhibitor of polo-like kinase 1

Published in Molecular Cancer Therapeutics • Feb 1, 2007

Authors:

Timothy J. Lansing

Randy T. McConnell

Derek R. Duckett

Abstract

Polo-like kinase 1 (PLK1) plays key roles in the regulation of mitotic progression, including mitotic entry, spindle formation, chromosome segregation, and cytokinesis. PLK1 expression and activity are strongly linked to proliferating cells. Many studies have shown that PLK1 expression is elevated i...

Subject

PLK1

Polo-like kinase

Mitosis

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!