A New
            <i>Aspergillus fumigatus</i>
            Resistance Mechanism Conferring In Vitro Cross-Resistance to Azole Antifungals Involves a Combination of
            <i>cyp51A</i>
            Alterations

Mellado, E.; Garcia-Effron, G.; Alcázar-Fuoli, L.; J. G. Melchers, W.; E. Verweij, P.; Cuenca-Estrella, M.; L. Rodríguez-Tudela, J.

doi:10.1128/aac.01092-06

Public

A New Aspergillus fumigatus Resistance Mechanism Conferring In Vitro Cross-Resistance to Azole Antifungals Involves a Combination of cyp51A Alterations

Shared by NobleBlocks on Jun 1, 2007 • 12:00 AM UTC

Authors:

E. Mellado

G. Garcia-Effron

L. Alcázar-Fuoli

Abstract

ABSTRACT Fourteen Aspergillus fumigatus clinical isolates that exhibited a pattern of reduced susceptibility to triazole drugs were analyzed. The sequences of the cyp51A gene from all isolates showed the presence of a point mutation at t364a, which led to the substitution of leucine 98 for histidine...

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