β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes

E. Butler, Alexandra; Janson, Juliette; Bonner-Weir, Susan; Ritzel, Robert; A. Rizza, Robert; C. Butler, Peter

doi:10.2337/diabetes.52.1.102

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β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes

Shared by NobleBlocks on Jan 1, 2003 • 12:00 AM UTC

Authors:

Alexandra E. Butler

Juliette Janson

Susan Bonner-Weir

Abstract

Type 2 diabetes is characterized by impaired insulin secretion. Some but not all studies suggest that a decrease in β-cell mass contributes to this. We examined pancreatic tissue from 124 autopsies: 91 obese cases (BMI >27 kg/m2; 41 with type 2 diabetes, 15 with impaired fasting glucose [IFG], and 3...

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