T Follicular Helper Cells Express a Distinctive Transcriptional Profile, Reflecting Their Role as Non-Th1/Th2 Effector Cells That Provide Help for B Cells

Chtanova, Tatyana; G Tangye, Stuart; Newton, Rebecca; Frank, Nita; R Hodge, Martin; S Rolph, Michael; R Mackay, Charles

doi:10.4049/jimmunol.173.1.68

Public

T Follicular Helper Cells Express a Distinctive Transcriptional Profile, Reflecting Their Role as Non-Th1/Th2 Effector Cells That Provide Help for B Cells

Shared by NobleBlocks on Jul 1, 2004 • 12:00 AM UTC

Authors:

Tatyana Chtanova

Stuart G Tangye

Rebecca Newton

Abstract

Abstract Effector T cell responses have long been viewed in the context of the Th1/Th2 paradigm. Recently, a third major subset of nonpolarized effector T cells that provides help to B cells has been identified. These T cells, termed T follicular helper (TFH) cells, home to the B cell areas of secon...

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