Bilirubin decreases NOS2 expression via inhibition of NAD(P)H oxidase: implications for protection against endotoxic shock in rats

Lanone, Sophie; Bloc, Sébastien; Foresti, Roberta; Almolki, Abdelhamid; Taillé, Camille; Callebert, Jacques; Conti, Marc; Goven, Delphine; Aubier, Michel; Dureuil, B.; El‐Benna, Jamel; Mottierlini, Roberto; Boczkowski, Jorge

doi:10.1096/fj.04-2368fje

Public

Bilirubin decreases NOS2 expression via inhibition of NAD(P)H oxidase: implications for protection against endotoxic shock in rats

Published in The FASEB Journal • Aug 29, 2005

Authors:

Sophie Lanone

Sébastien Bloc

Roberta Foresti

Abstract

We investigated a possible beneficial role for bilirubin, one of the products of heme degradation by the cytoprotective enzyme heme oxygenase-1 in counteracting Escherichia coli endotoxin-mediated toxicity. Homozygous jaundice Gunn rats, which display high plasma bilirubin levels due to deficiency o...

Subject

Bilirubin

NAD+ kinase

Heme

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