Effect of Vericiguat, a Soluble Guanylate Cyclase Stimulator, on Natriuretic Peptide Levels in Patients With Worsening Chronic Heart Failure and Reduced Ejection Fraction

Gheorghiade, Mihai; J. Greene, Stephen; Butler, Javed; Filippatos, Gerasimos; S.P. Lam, Carolyn; P. Maggioni, Aldo; Ponikowski, Piotr; J. Shah, Sanjiv; D. Solomon, Scott; Kraigher‐Krainer, Elisabeth; T. Samano, Eliana; Müller, Katharina; Roessig, Lothar; Pieske, Burkert; the SOCRATES-REDUCED Investigators and Coordinators, for

doi:10.1001/jama.2015.15734

Public

Effect of Vericiguat, a Soluble Guanylate Cyclase Stimulator, on Natriuretic Peptide Levels in Patients With Worsening Chronic Heart Failure and Reduced Ejection Fraction

Published in JAMA • Nov 8, 2015

Authors:

Mihai Gheorghiade

Stephen J. Greene

Javed Butler

Abstract

IMPORTANCE: Worsening chronic heart failure (HF) is a major public health problem. OBJECTIVE: To determine the optimal dose and tolerability of vericiguat, a soluble guanylate cyclase stimulator, in patients with worsening chronic HF and reduced left ventricular ejection fraction (LVEF). DESIGN, SET...

Subject

Medicine

Ejection fraction

Heart failure

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