Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development

REDFERN, W; Carlsson, Leif; Davis, Alice; G. Lynch, W.; C. Mackenzie, Ian; PALETHORPE, S; K. S. Siegl, Peter; Strang, I.; SULLIVAN, A; Wallis, Russell

doi:10.1016/s0008-6363(02)00846-5

Public

Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development

Published in Cardiovascular Research • Apr 1, 2003

Authors:

W REDFERN

Leif Carlsson

Alice Davis

Abstract

OBJECTIVE: To attempt to determine the relative value of preclinical cardiac electrophysiology data (in vitro and in vivo) for predicting risk of torsade de pointes (TdP) in clinical use. METHODS: Published data on hERG (or I(Kr)) activity, cardiac action potential duration (at 90% repolarisation; A...

Subject

hERG

QT interval

Prolongation

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