Transcription Factor Nrf2 Regulates Inflammation by Mediating the Effect of 15-Deoxy-Δ<sup>12,14</sup>-Prostaglandin J<sub>2</sub>

Itoh, Ken; Mochizuki, M.; Ishii, Yukio; Ishii, Tetsuro; Shibata, Takahiro; Kawamoto, Yoshiyuki; P. Kelly, Vincent; Sekizawa, Kiyohisa; Uchida, Kôji; Yamamoto, Masayuki

doi:10.1128/mcb.24.1.36-45.2004

Public

Transcription Factor Nrf2 Regulates Inflammation by Mediating the Effect of 15-Deoxy-Δ12,14-Prostaglandin J2

Published in Molecular and Cellular Biology • Dec 12, 2003

Authors:

Ken Itoh

M. Mochizuki

Yukio Ishii

Abstract

Activated macrophages express high levels of Nrf2, a transcription factor that positively regulates the gene expression of antioxidant and detoxication enzymes. In this study, we examined how Nrf2 contributes to the anti-inflammatory process. As a model system of acute inflammation, we administered ...

Subject

Biology

Transcription factor

Inflammation

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