DPA-714, a New Translocator Protein–Specific Ligand: Synthesis, Radiofluorination, and Pharmacologic Characterization

L. James, Michelle; Fulton, Roger; Vercoullie, Johnny; Henderson, David; Garreau, Lucette; Chalon, Sylvie; Dollé, Frédéric; Selleri, Silvia; Guilloteau, Denis; Kassiou, Michael

doi:10.2967/jnumed.107.046151

Public

DPA-714, a New Translocator Protein–Specific Ligand: Synthesis, Radiofluorination, and Pharmacologic Characterization

Published in Journal of Nuclear Medicine • Apr 15, 2008

Authors:

Michelle L. James

Roger Fulton

Johnny Vercoullie

Abstract

UNLABELLED: The translocator protein (18 kDa) (TSPO), formerly known as the peripheral benzodiazepine receptor, is dramatically upregulated under pathologic conditions. Activated microglia are the main cell type expressing the TSPO at sites of central nervous system pathology. Radioligands for the T...

Subject

Translocator protein

Radioligand

Chemistry

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