TNF Regulates Chemokine Induction Essential for Cell Recruitment, Granuloma Formation, and Clearance of Mycobacterial Infection

R. Roach, Daniel; G. D. Bean, Andrew; Demangel, Caroline; P. France, Malcolm; Briscoe, Helen; J. Britton, Warwick

doi:10.4049/jimmunol.168.9.4620

Public

TNF Regulates Chemokine Induction Essential for Cell Recruitment, Granuloma Formation, and Clearance of Mycobacterial Infection

Published in The Journal of Immunology • May 1, 2002

Authors:

Daniel R. Roach

Andrew G. D. Bean

Caroline Demangel

Abstract

Host immunity to mycobacterial infection is dependent on the activation of T lymphocytes and their recruitment with monocytes to form granulomas. These discrete foci of activated macrophages and lymphocytes provide a microenvironment for containing the infection. The cytokine, TNF, is essential for ...

Subject

Chemokine

Tumor necrosis factor alpha

Immunology

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