A SUMOylation-Dependent Pathway Regulates SIRT1 Transcription and Lung Cancer Metastasis

Sun, Lina; Li, He; Chen, Junliang; Dehennaut, Vanessa; Zhao, Yuhao; Yang, Yuyu; Iwasaki, Yasumasa; Kahn‐Perlès, Brigitte; Leprince, Dominique; Chen, Qi; Shen, Aiguo; Xu, Yong

doi:10.1093/jnci/djt118

Public

A SUMOylation-Dependent Pathway Regulates SIRT1 Transcription and Lung Cancer Metastasis

Published in JNCI Journal of the National Cancer Institute • May 24, 2013

Authors:

Lina Sun

He Li

Junliang Chen

Abstract

BACKGROUND: Epithelial-to-mesenchymal transition (EMT) plays a pivotal role in lung cancer metastasis. The class III deacetylase sirtuin 1 (SIRT1) possesses both pro- and anticarcinogenic properties. The role of SIRT1 in lung cancer EMT is largely undefined. METHODS: The effect of SIRT1 on migration...

Subject

Cancer research

Lung cancer

Metastasis

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