Activation of Human Orbital Fibroblasts through CD40 Engagement Results in a Dramatic Induction of Hyaluronan Synthesis and Prostaglandin Endoperoxide H Synthase-2 Expression

Cao, Hanwei; Wang, Hwai-Shi; Zhang, Ying; Lin, Hung‐Yun; P. Phipps, Richard; J. Smith, Terry

doi:10.1074/jbc.273.45.29615

Public

Activation of Human Orbital Fibroblasts through CD40 Engagement Results in a Dramatic Induction of Hyaluronan Synthesis and Prostaglandin Endoperoxide H Synthase-2 Expression

Published in Journal of Biological Chemistry • Nov 1, 1998

Authors:

Hanwei Cao

Hwai-Shi Wang

Ying Zhang

Abstract

Human orbital fibroblasts play a putative role in the pathogenesis of thyroid-associated ophthalmopathy (TAO). We hypothesize that the hyaluronan accumulation and inflammation in TAO derive from enhanced biosynthetic activities of orbital fibroblasts. CD40, a member of the tumor necrosis factor-alph...

Subject

CD40

Chemistry

Cell biology

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