Endogenous IL-33 enhances Th2 cytokine production and T-cell responses during allergic airway inflammation

Louten, Jennifer; L. Rankin, Andrew; Li, Ying; E. Murphy, Erin; Beaumont, Maribel; Moon, Christina; Bourne, Patricia; K. McClanahan, Terrill; Pflanz, Stefan; de Waal Malefyt, René

doi:10.1093/intimm/dxr006

Public

Endogenous IL-33 enhances Th2 cytokine production and T-cell responses during allergic airway inflammation

Published in International Immunology • Mar 21, 2011

Authors:

Jennifer Louten

Andrew L. Rankin

Ying Li

Abstract

IL-33 is an IL-1-related cytokine which has been implicated in T(h)2-associated biology and allergic diseases in humans and mice. IL-33 stimulates T(h)2 cells, mast cells, eosinophils, basophils, iNKT cells and circulating CD34(+) stem cells to proliferate and produce pro-allergic cytokines such as ...

Subject

Immunology

Allergic inflammation

Cytokine

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