Contrasting disease patterns in seropositive and seronegative neuromyelitis optica: A multicentre study of 175 patients

Jarius, Sven; Ruprecht, Klemens; Wildemann, Brigitte; Kuempfel, Tania; Ringelstein, Marius; Geis, Christian; Kleiter, Ingo; Kleinschnitz, Christoph; Berthele, Achim; Brettschneider, Johannes; Hellwig, Kerstin; Hemmer, Bernhard; A. Linker, Ralf; Lauda, Florian; Mayer, Christoph; Tumani, Hayrettin; Melms, Arthur; Trebst, Corinna; Stangel, Martin; Marziniak, Martin; Hoffmann, Frank; Schippling, Sven; Faiss, Jürgen; Neuhaus, Oliver; Ettrich, Barbara; Zentner, Christian; Guthke, Kersten; Hofstadt‐van Oy, Ulrich; Reuß, Reinhard; Pellkofer, Hannah; Ziemann, Ulf; Kern, Peter; Wandinger, K.-P.; Then Bergh, Florian; Boettcher, Tobias; Langel, Stefan; Liebetrau, Martin; Rommer, Paulus; Niehaus, Sabine; Münch, Christoph; Winkelmann, Alexander; K Zettl U, Uwe; Metz, Imke; Veauthier, Christian; Peter Sieb, Jörn; Wilke, Christian; Hartung, Hans; Aktaş, Orhan; Paul, Friedemann

doi:10.1186/1742-2094-9-14

Public

Contrasting disease patterns in seropositive and seronegative neuromyelitis optica: A multicentre study of 175 patients

Published in Journal of Neuroinflammation • Jan 19, 2012

Authors:

Sven Jarius

Klemens Ruprecht

Brigitte Wildemann

Abstract

BACKGROUND: The diagnostic and pathophysiological relevance of antibodies to aquaporin-4 (AQP4-Ab) in patients with neuromyelitis optica spectrum disorders (NMOSD) has been intensively studied. However, little is known so far about the clinical impact of AQP4-Ab seropositivity. OBJECTIVE: To analyse...

Subject

Medicine

Neuromyelitis optica

Myelitis

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