Differential expression of PDE4 cAMP phosphodiesterase isoforms in inflammatory cells of smokers with COPD, smokers without COPD, and nonsmokers

Barber, Rachael; S. Baillie, George; Bergmann, Reinhard; Shepherd, Malcolm; Sepper, Ruth; D. Houslay, Miles; Van Heeke, Gino

doi:10.1152/ajplung.00384.2003

Public

Differential expression of PDE4 cAMP phosphodiesterase isoforms in inflammatory cells of smokers with COPD, smokers without COPD, and nonsmokers

Published in American Journal of Physiology-Lung Cellular and Molecular Physiology • Mar 30, 2004

Authors:

Rachael Barber

George S. Baillie

Reinhard Bergmann

Abstract

The expression profile of a panel of 15 cAMP phosphodiesterase isoforms was determined for inflammatory cell types of relevance to chronic obstructive pulmonary disease (COPD). In particular, the expression profiles for bronchoalveolar macrophages, peripheral blood monocytes, T lymphocytes, and neut...

Subject

COPD

Bronchoalveolar lavage

Phosphodiesterase

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