Comprehensive Genomic Analysis Identifies Novel Subtypes and Targets of Triple-Negative Breast Cancer

D. Burstein, Matthew; Tsimelzon, Anna; M. Poage, Graham; R. Covington, Kyle; Contreras, Alejandro; A.W. Fuqua, Suzanne; I. Savage, Michelle; Kent Osborne, C.; G. Hilsenbeck, Susan; C. Chang, Jenny; B. Mills, Gordon; C. Lau, Ching; H. Brown, Powel

doi:10.1158/1078-0432.ccr-14-0432

Public

Comprehensive Genomic Analysis Identifies Novel Subtypes and Targets of Triple-Negative Breast Cancer

Published in Clinical Cancer Research • Sep 11, 2014

Authors:

Matthew D. Burstein

Anna Tsimelzon

Graham M. Poage

Abstract

PURPOSE: Genomic profiling studies suggest that triple-negative breast cancer (TNBC) is a heterogeneous disease. In this study, we sought to define TNBC subtypes and identify subtype-specific markers and targets. EXPERIMENTAL DESIGN: RNA and DNA profiling analyses were conducted on 198 TNBC tumors [...

Subject

Triple-negative breast cancer

Breast cancer

Cancer research

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