Specific HIV integration sites are linked to clonal expansion and persistence of infected cells

Maldarelli, Frank; Wu, Xiaolin; Su, Li; R. Simonetti, Francesco; Shao, Wei; Hill, S.; Spindler, Jonathan; L. Ferris, Andrea; W. Mellors, John; F. Kearney, Mary; M. Coffin, John; H. Hughes, Stephen

doi:10.1126/science.1254194

Public

Specific HIV integration sites are linked to clonal expansion and persistence of infected cells

Published in Science • Jun 27, 2014

Authors:

Frank Maldarelli

Xiaolin Wu

Li Su

Abstract

The persistence of HIV-infected cells in individuals on suppressive combination antiretroviral therapy (cART) presents a major barrier for curing HIV infections. HIV integrates its DNA into many sites in the host genome; we identified 2410 integration sites in peripheral blood lymphocytes of five in...

Subject

Persistence (discontinuity)

Human immunodeficiency virus (HIV)

Biology

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