Adoptive immunotherapy with liver allograft-derived lymphocytes induces anti-HCV activity after liver transplantation in humans and humanized mice.

M, Ohira; K, Ishiyama; Y, Tanaka; M, Doskali; M, Doskali; Y, Igarashi; H, Tashiro; N, Hiraga; M, Imamura; N, Sakamoto; T, Asahara; K, Chayama; H, Ohdan

doi:10.1172/jci38374

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Adoptive immunotherapy with liver allograft-derived lymphocytes induces anti-HCV activity after liver transplantation in humans and humanized mice.

Shared by NobleBlocks on Oct 1, 2009 • 12:00 AM UTC

Authors:

Ohira M

Ishiyama K

Tanaka Y

Abstract

After liver transplantation in HCV-infected patients, the virus load inevitably exceeds pre-transplantation levels. This phenomenon reflects suppression of the host-effector immune responses that control HCV replication by the immunosuppressive drugs used to prevent rejection of the transplanted liv...

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