TH17 Cells Mediate Steroid-Resistant Airway Inflammation and Airway Hyperresponsiveness in Mice

McKinley, Laura; F. Alcorn, John; Peterson, Alanna; DuPont, Rachel; B Kapadia, Shernaaz; Logar, Alison; C. Henry, Adam; G. Irvin, Charles; D. Piganelli, Jon; Ray, Anuradha; K. Kolls, Jay

doi:10.4049/jimmunol.181.6.4089

Public

TH17 Cells Mediate Steroid-Resistant Airway Inflammation and Airway Hyperresponsiveness in Mice

Published in The Journal of Immunology • Sep 1, 2008

Authors:

Laura McKinley

John F. Alcorn

Alanna Peterson

Abstract

Steroid-resistant asthma comprises an important source of morbidity in patient populations. T(H)17 cells represent a distinct population of CD4(+) Th cells that mediate neutrophilic inflammation and are characterized by the production of IL-17, IL-22, and IL-6. To investigate the function of T(H)17 ...

Subject

Immunology

Inflammation

Eosinophil

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