Cells Deficient in the FANC/BRCA Pathway Are Hypersensitive to Plasma Levels of Formaldehyde

R. Ridpath, John; Nakamura, Ayumi; Tano, Keizo; M. Luke, April; Sonoda, Eiichiro; Arakawa, Hiroshi; Buerstedde, Jean-Marie; A. Gillespie, David; E. Sale, Julian; Yamazoe, Mitsuyoshi; K. Bishop, Douglas; Takata, Minoru; Takeda, Shunichi; Watanabe, Masami; A. Swenberg, James; Nakamura, Jun

doi:10.1158/0008-5472.can-07-3028

Public

Cells Deficient in the FANC/BRCA Pathway Are Hypersensitive to Plasma Levels of Formaldehyde

Published in Cancer Research • Dec 1, 2007

Authors:

John R. Ridpath

Ayumi Nakamura

Keizo Tano

Abstract

Formaldehyde is an aliphatic monoaldehyde and is a highly reactive environmental human carcinogen. Whereas humans are continuously exposed to exogenous formaldehyde, this reactive aldehyde is a naturally occurring biological compound that is present in human plasma at concentrations ranging from 13 ...

Subject

DNA damage

Fanconi anemia

FANCD2

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