Comparative Genomic Analysis of Esophageal Adenocarcinoma and Squamous Cell Carcinoma

Agrawal, Nishant; Jiao, Yuchen; Bettegowda, Chetan; Hutfless, Susan; Wang, Yuxuan; David, Stefan; Cheng, Yulan; S. Twaddell, William; L. Latt, Nyan; Ji Shin, Eun; Wang, Lidong; Wang, Liang; Yang, Wancai; E. Velculescu, Victor; Vogelstein, Bert; Papadopoulos, Nickolas; W. Kinzler, Kenneth; J. Meltzer, Stephen

doi:10.1158/2159-8290.cd-12-0189

Public

Comparative Genomic Analysis of Esophageal Adenocarcinoma and Squamous Cell Carcinoma

Published in Cancer Discovery • Aug 10, 2012

Authors:

Nishant Agrawal

Yuchen Jiao

Chetan Bettegowda

Abstract

Abstract Esophageal cancer ranks sixth in cancer death. To explore its genetic origins, we conducted exomic sequencing on 11 esophageal adenocarcinomas (EAC) and 12 esophageal squamous cell carcinomas (ESCC) from the United States. Interestingly, inactivating mutations of NOTCH1 were identified in 2...

Subject

Esophagus

Esophageal cancer

Esophageal squamous cell carcinoma

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