A pyrazolato-bridged dinuclear platinum(II) complex induces only minor distortions upon DNA-binding.

S, Teletchéa; S, Komeda; JM, Teuben; MA, Elizondo-Riojas; J, Reedijk; J, Kozelka

doi:10.1002/chem.200500923

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A pyrazolato-bridged dinuclear platinum(II) complex induces only minor distortions upon DNA-binding.

Shared by NobleBlocks on May 1, 2006 • 12:00 AM UTC

Authors:

Teletchéa S

Komeda S

Teuben JM

Abstract

The cytotoxic, pyrazolato-bridged dinuclear platinum(II) complex [(cis-{Pt(NH3)2})2(mu-OH)(mu-pz)]2+ (pz=pyrazolate) has been found to cross-link two adjacent guanines of a double-stranded DNA decamer without destabilizing the duplex and without changing the directionality of the helix axis. A 1H NM...

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